IRF3 and neoplasm: In these macrophages, CD91 and TLR4 receptor complex-associated MyD88−IRAK1/4−IKKα/β−NF-κB/IRF3 and MyD88−JAK2/TYK2−STAT-3 signaling pathways are elicited to cause several events for tumor-promoting M2-polarization, such as downregulation of inflammatory cytokines as well as upregulation of M2 markers, phagocytosis repressors, and angiogenesis activators (Figure 7).