Hyperactivation of the PI3K/AKT/mTOR pathway, including consistent detection of hyperphosphorylation of AKT-Ser473, which we also confirmed in AZA-R subclones, can be typically found in patients with chemoresistant AML, likely related to a mechanism that allows leukemic stem cells to survive [28]. This evidence concerns the gene PIK3CD and acute myeloid leukemia.