The transcriptomic analysis using RNAsec revealed 2865 differentially expressed mRNAs between AZA-S and AZA-R (adjusted p < 0.05; mRNAs with at least 1-fold down/up-regulation are shown in Figure 2A), which were enriched for several key biological processes related to apoptosis, chemokine signaling, PI3K/AKT, RAP1, TNF, TGF, and cancer (Figure 2B and Figure S2A). This evidence concerns the gene PIK3CD and cancer.