Using sequencing of a panel of 33 MDS-related genes [24] we detected variants in some of them (ASXL1, BCORL1, TP53, TET2, CSF3R, NRAS) in the AZA-R subclones, none of which, however, arose newly (Figure S1E). This evidence concerns the gene BCORL1 and myelodysplastic syndrome.