Despite the uncertainty of how pDCs function to induce anti-tumor immunity, however, pDCs likely play some roles in regulating cross-priming to generate CD8 T cell immunity, as increasing evidences have shown that cooperation of pDCs and cDCs are required to induce optimal cross-priming and CD8 T cell immunity under different settings [80,89,90,91,92,93]. This evidence concerns the gene CD8A and neoplasm.