HMGB1 and myocardial infarction: Surprisingly, four weeks after MI, they did not have significant functional improvements neither by echocardiography nor by hemodynamic analysis (only after 1 wk but not after 2 and 4 wk) following injection of fr-HMGB1 compared to controls, even though they adopted an identical protocol and the same time points for functional measurements present in the study by Limana et al. [155].