HMGB1 and myocardial infarction: Interestingly, the interplay between fr-HMGB1 and ds-HMGB1 is a reversible process while ox-HMGB1 is irreversibly transformed and this progressive oxidation of the protein is fundamental to correctly coordinate the functions of all the cellular effectors involved in the inflammatory and reparative response following myocardial infarction.