Secondly, it has been shown in CAD patients that ACKR3/CXCR7 mediated signaling involving Erk regulates the re-endothelialization capacity of regenerative endothelial outgrowth cells (EOC), which play an important role in revascularization of the ischemic organ, quite independent of any influence from circulating platelets. This evidence concerns the gene ACKR3 and coronary artery disorder.