However, plasma levels of CXCL12/SDF1-α [12,38] and MIF [45] are elevated in CAD patients, which, combined with increased surface availability of both CXCR4 and ACKR3/CXCR7 on platelets [23,25], may decide on the balance between pro- and anti-thrombotic functions. This evidence concerns the gene CXCL12 and coronary artery disorder.