TARDBP and amyotrophic lateral sclerosis: In a tissue-engineered model derived from fibroblasts of 12 ALS patients (six sporadic and six familial C9ORF72 cases), an increased accumulation of cytoplasmic TDP-43 was found in ALS patients (30%) compared to HC (4%) in epidermis, dermo-epidermal junction, and dermis [14].