TARDBP and amyotrophic lateral sclerosis: Considering the proportion of TDP-43 immunoreactivity in the dermis, ROC analyses showed an AUC of 0.911 (p < 0.001, CI 95% 0.862–0.960) and cut-off values of 0.26%, with 88.6% sensitivity, 82.5% specificity, 91.8% positive predictive value and 76.7% negative predictive value for detecting ALS.