In patients with pulmonary tuberculosis, lower GPR183 expression in the blood correlated significantly with more severe disease on chest X-ray, and GPR183 KO mice exhibited a higher lung mycobacterial burden and dysregulated type I IFNs in early infection [35], highlighting the important roles of oxysterols and GPR183 in the immune response to mycobacterial infections. Here, GPR183 is linked to pulmonary tuberculosis.