AML genomes, in general, carry several mutations, their number being related to patient’s age, and many frequently mutated genes have been reported across the years, such as DNMT3A [3], FLT3 [4], NPM1 [5], IDH1 [6], IDH2 [7], WT1 [8], EZH2 [9,10], RUNX1 [11], PTPRT [12], PHF6 [13], ETV6 [14], ASXL1, MLL, CEBPA, KIT [15], TET2 [16], KRAS [17], WAC, SMC3, DIS3, DDX41, and DAXX [18]. This evidence concerns the gene RUNX1 and acute myeloid leukemia.