By considering the results from Chipumuro and colleagues testing the efficacy of THZ1 with increasing concentrations on MYCN-amplified NB cells and untransformed cells (murine fibroblasts), 100 nM of THZ1 is sufficient to massively decrease the viability of MYCN-amplified NB cells, to 20% or less considering cell lines, but also leads to a decreased viability of untransformed cells, reaching 50% [81]. Here, MYCN is linked to neuroblastoma.