MYCN and neuroblastoma: THZ1, a CDK7 inhibitor, is able to prevent RNA pol II phosphorylation [79] and was demonstrated to lead to an accumulation of RNA polymerases at gene bodies [80], as well as a downregulation of SE-associated genes, including MYCN in neuroblastoma (NB) cells [81] and RUNX1 in T-ALL [82], inhibiting, in this way, tumor growth.