ADH1B and cancer: So far, only the functional rs1229984 in ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), characterized by a G > A transition with an amino acidic change from arginine (Arg) to histidine (His), has been reported to be associated with cancer risk among Caucasians (increased risk, A allele MAF ≥ 0.03) and Asians (decreased risk, A allele MAF ≥ 0.3).