A GTT experiment showed a higher glycemic response to intraperitoneal injection of glucose in AUTXKO animals in comparison to fl/Y animals (Figure 6A), while an ITT experiment revealed a blunted hypoglycemic response to intraperitoneal injection of insulin in the knockout mice (Figure 6B), suggesting that Utx deficiency in adipocytes causes glucose intolerance and insulin resistance. The gene discussed is INS; the disease is Insulin resistance.