INS and Glucose intolerance: A GTT experiment showed a higher glycemic response to intraperitoneal injection of glucose in AUTXKO animals in comparison to fl/Y animals (Figure 6A), while an ITT experiment revealed a blunted hypoglycemic response to intraperitoneal injection of insulin in the knockout mice (Figure 6B), suggesting that Utx deficiency in adipocytes causes glucose intolerance and insulin resistance.