MALAT1 and cerebrovascular disorder: While MALAT1 has been reported to be downregulated and primarily play an anti-inflammatory role in patients with cerebrovascular disease [53], MALAT1 expression is negatively correlated with NIHSS (National Institutes of Health Stroke Scale) score and pro-inflammatory factor expression (including CRP, TNF-α, IL-6, IL-8, and IL-22) in acute ischemic stroke (AIS) patients.