NLGN4X and EAST syndrome: Variants of this protein cause SESAME syndrome, a complex neurological disease; (b) 25 highly clustered postsynaptic membrane proteins (Figure 5E), including dystrophin (UniProt ID: P11532), a component of the dystrophin-associated glycoprotein complex localized at a variety of synapses in the nervous system and the neuromuscular junction, encoded by DMD, the causal gene of Duchenne muscular dystrophy, and Neuroligin-4 (UniProt ID: Q8N0W4) encoded by NLGN4X, associated with X-linked autism and Asperger syndrome [52]; (c) 12 highly interconnected PDZ domain proteins (Figure 5F).