NTSR1 and neoplasm: Moreover, Kanada et al. demonstrated that tumour-derived microvesicles loaded with a minicircle DNA encoding the prodrug converting enzymes, thymidine kinase (TK)/nitroreductase (NTR), led to the effective killing of BC cells via TK-NTR-mediated conversion of co-delivered prodrugs into active cytotoxic agents [249].