A similar approach was used by Cheng et al. who generated SMART-Exos expressing monoclonal antibodies specific for T cells CD3 and cancer cell-associated EGFR, which induced both cross-linking of T cells and EGFR-expressing BC cells, but also elicited potent anti-tumour immunity both in vitro and in vivo [224]. The gene discussed is EGFR; the disease is breast cancer.