Similarly, Ham et al. revealed that the IL-6 receptor, glycoprotein 130 (gp130) packaged in BC cell-derived EVs, stimulates IL6/STAT3 signalling in bone marrow-derived macrophages (BMDMs), promoting BMDM survival and inducing the switching of BMDMs toward a cancer-promoting phenotype [116]. The gene discussed is STAT3; the disease is cancer.