AKT1 and breast cancer: Furthermore, Piao et al. highlighted how macrophage polarisation, induced by BC cell-derived EVs, can create favourable conditions for lymph node metastasis in TNBC [117], while Chen et al. reported that EV miR-222 from adriamycin-resistant MCF-7 BC cells promote M2 polarisation via PTEN/AKT to induce tumour progression [118].