MME and Alzheimer disease: The severe accumulation of Aβ peptides within brain tissue, starting years or even decades prior to the first symptoms, is considered as an important factor of AD pathogenesis, caused by an imbalance between Aβ production and Aβ clearance by Aβ-degrading enzymes such as insulin-degrading enzyme (IDE) and neprilysin (NEP) [17,18].