Transgenic mice overexpressing the Swedish mutation of AD (Tg2576), leading to increased γ-secretase cleavage of APP and thus Aβ levels, fed with a diet deficient in folate, vitamin B6 and vitamin B12 for 7 months, revealed significantly elevated Aβ peptide levels in the hippocampus and cortex compared to Tg2576 fed with a control diet [133]. Here, APP is linked to Alzheimer disease.