Indeed, some mechanisms of action have been proposed to underly Lf anticancer activity such as cell cycle arrest, apoptosis, and ferroptosis induction (triggered by low iron-saturated and saturated form, respectively), immunomodulation against cancer, inhibition of vascular endothelial growth factor (VEGF)-mediated angiogenesis, and reversion of epithelium-to-mesenchymal transition leading to metastasis inhibition [31,32,33,34,35,36,37,38,39]. The gene discussed is LTF; the disease is cancer.