PTGER2 and Thromboembolism: From the analysis of the docking poses, it was clear that both compounds are able to interact significantly with COX-2, 5-LO, PAFR, and mPGES-1, which are key proteins involved not only in the onset of inflammation but also with a cardiovascular alteration of platelet activity (and hyper-reactivity) and, to a lesser extent, thrombotic and thromboembolic disease [112,113].