In recent years, experimental and clinical data have been accumulating, indicating that along with the known triggers of neurodegeneration in PD, such as neuroinflammation and the neurotoxic effect of pathologically altered, aggregated alpha-synuclein [7,8], an important role in the pathogenesis of PD is played by disturbed sphingolipid metabolism [9,10]. Here, SNCA is linked to Parkinson disease.