Significantly, when the effect of hrsACE2 in the subgroup of chronic HF patients treated with angiotensin receptor blockers was compared with chronic HF patients treated with angiotensin converting enzyme inhibitors (ACEIs), the AT2 was found to be lowered, thereby increasing the AT1-7/AT2 ratio, but the AT1-7 was only mildly increased, with a relatively dominant increase in plasma angiotensin 1–5 (AT1-5). This evidence concerns the gene AGTR2 and hydrops fetalis.