Soluble Klotho could inhibit the PI3K/AKT/mTORC1 signaling to upregulate peroxisome proliferator-activated receptor α (PPARα) expression by directly interacting with type 1 insulin-like growth factor (IGF1) receptor in high fat diet-fed type 2 diabetes mellitus mice [10]. This evidence concerns the gene AKT1 and type 2 diabetes mellitus.