Several studies have pointed out the role of specific genes, such as patatin-like phospholipase containing 3 gene (PNPA3), farnesyl-diphosphate farnesyl transferase 1 gene (FDFT1), transmembrane 6 superfamily protein 2 gene (TM6SF2), glucokinase regulator gene (GCKR), and membrane bound O acyltransferase domain containing 7 gene (MBOAT7), in the development and progression of NAFLD to NASH and HCC [12,13,14,15,16,17,18]. The gene discussed is MBOAT7; the disease is hepatocellular carcinoma.