PNPLA2 and liver disorder: Furthermore, in recent years, the generation of transgenic mice with global- and/or tissue-specific ATGL ablation and cellular models of ATGL manipulations, as well as patients with ATGL-related mutations, have deepened our understanding about the pivotal role of ATGL in regulating hepatic lipid homeostasis and the progression of liver diseases [21,79,80,81,82].