Studies showed an increased expression of MCM5 and a positive correlation with Ki-67 [33], as well as an increased expression of MCM2, MCM3, and MCM7 in Larynx Epidermoid Carcinoma 2 (HEp-2) cell lines and positive correlations with Ki-67 in LSCC [34]. This evidence concerns the gene MCM3 and squamous cell carcinoma.