Study performed by Ou et al. [30], using human umbilical vein endothelial cells (HUVECs), showed that exogenous addition of galectin-3 and oxidised low-density lipoprotein (oxLDL) to cell cultures increased the expression of lectin-like oxLDL receptor 1 (LOX-1) and promoted endothelial dysfunction via LOX-1/ROS/p38/NF-kB-mediated signalling pathway. Here, LGALS3 is linked to endothelial dysfunction.