KDM2A activity decreased rRNA transcription and the proliferation of breast cancer cells, such as MCF-7 cells, in response to glucose starvation, the anti-diabetic drug metformin, and the food-additive gallic acid [3,4,5-trihydroxybenzoic acid] [6,12,13,14,15]. This evidence concerns the gene KDM2A and breast carcinoma.