Similarly, Schleiermacher et al. reported that a higher number of chromosome breakpoints (BPs) correlated with an advanced stage of disease and a poorer outcome [16], and proposed a tumor subclassification using the structural alterations of ‘segmental chromosome aberration (SCA)’ and ‘numerical chromosome aberration (NCA)’ in addition to the MYCN amplification [14]. This evidence concerns the gene MYCN and neoplasm.