The authors used in vivo models of Lm-infected B6.Il18−/−, B6.Il18r−/−, B6.Nlrp3−/−, and B6.Batf3−/− mice in which they found almost undetectable serum IL-10 and reduced Lm burdens in the spleen and liver compared to B6 mice at 72 h post-infection, showing the relevance of IL-18, IL-18R1, NLRP3, and Batf3 for IL-10 production and resistance to Lm systemic infection. Here, IL10 is linked to infection.