NLRP3 and infection: In that study, the levels of serum IL-18 were also found to be increased in parallel with those of serum IL-10 in Lm-infected B6 mice at 72 h post-infection, whereas B6.Nlrp3−/− mice had significantly reduced serum IL-18, which indicated that NLRP3 expression is relevant for IL-18 production.