Under these conditions, the activation of NF-κB in tumor cells [51,56], as well as M1 and M2 macrophages, leads to the secretion of tumor necrosis factor-alpha (TNF-α) and other cytokines, such as interleukin-1 (IL-1), IL-6, IL-12, IL-10, and IL-13 [52,57]. This evidence concerns the gene TNF and neoplasm.