Moreover, we showed the presence of EGFR, VEGFA, CXCR4 and HIF1-A mRNAs in CRC-EVs, which is in agreement with several evidences that support the involvement of these molecules in CRC development and metastases formation [26,55,56,57,58,59,60,61,62,63,64]. The gene discussed is CXCR4; the disease is colorectal carcinoma.