IFNB1 and Zika virus infectious disease: To examine the ability of IFNs to control ZIKV infection in astrocyte cells, IFN type I (IFN-β) and type III (IFN-λ) were assessed for their anti-ZIKV ability, because they have the ability to drive different sub-sets of interferon-stimulated genes, many of which are antiviral [71,72,73].