Interestingly, viperin mRNA was significantly induced much earlier in the ZIKV-resistant CFF-STGG1 cells (fold change 107.71 (MR766) and 92.93 (PRVABC59)) at 48-hour in response to ZIKV infection (Figure 3D), once again, despite the lowered viral replication in this cell line (Figure 1A and Figure 2A,B), but reached higher expression levels in the ZIKV-susceptible astrocytes (HASTR/ci35) at the later timepoint, demonstrating a delayed response in comparison with the more ZIKV-resistant astrocyte cells (Figure 3D, fold change 336.02 (MR766) and 277.89 (PRVABC59)). The gene discussed is RSAD2; the disease is Zika virus infectious disease.