This observation is in line with a previous report suggesting that a rapid type I IFN response may protect murine astrocytes from cell death following flavivirus infections including ZIKV [17]; however, future work in understanding the ability of one astrocyte cell line to control ZIKV infection over a similar cell line may add important knowledge in regard to further cellular host factors in control of this rapid IFN response. Here, IFNA1 is linked to Flavivirus Infections.