Furthermore, pre-treatment with higher IFN-β concentration (2000 U/mL) showed better control of ZIKV infection than a lower concentration (Figure 5 and Figure S2), but unlike IFN-β pre-treatment, no dose-dependent variation in ZIKV control was observed between the high and low amounts of IFN-λ pre-treated cells (Figure 5 and Figure S2). The gene discussed is IFNB1; the disease is Zika virus infectious disease.