This observation is in line with a previous report suggesting that a rapid type I IFN response may protect murine astrocytes from cell death following flavivirus infections including ZIKV [17]; however, future work in understanding the ability of one astrocyte cell line to control ZIKV infection over a similar cell line may add important knowledge in regard to further cellular host factors in control of this rapid IFN response. This evidence concerns the gene IFNA1 and Zika virus infectious disease.