Herein, unlike the classical TERT pathway that affects cell growth and survival (TERT → telomerase → TEL → senescence) [11,29,32], our results showed that TERT promoter revertant mutation in melanoma did not induce cellular senescence but abrogated the inhibitory effect of mutant TERT on apoptosis (TERT → telomerase →TEL → Bcl-2 → apoptosis). The gene discussed is TERT; the disease is melanoma.