The cytotoxicity induced by troglitazone in human renal cell carcinoma cell lines has been demonstrated to be independent by PPARγ pathway [77]; analogously, the antiproliferative effect induced by fenofibrate in human hepatoma cell line Huh7 was not related to PPARα stimulation, while this effect was not suppressed by using the selective PPARα antagonist GW6471 [78]. This evidence concerns the gene PPARA and hereditary clear cell renal cell carcinoma.