Previously, several transcription factors regulating Foxl2 specific expression have been revealed, such as HMGA2 in chemotherapy-resistant gastric cancer of M. musculus [23]; STAT3 in apoptosis of M. musculus HeLa cells [22,39]; while the regulation of Foxl2 transcription in gonads has only been reported in M. musculus, in which CTNNB1 was found to induce the transformation of Sertoli cells into granular cells by activating ectopic expression of Foxl2 in the testis of M. musculus [21]. Here, HMGA2 is linked to gastric cancer.