NPPB and hydrops fetalis: Moreover, the expression of Bnp, reflecting HF severity, was upregulated in the EAM hearts of the sham and F-sheet transplant groups, but not in those with QQ+F cell sheet grafts (Figure 7), and histochemical analysis revealed that the grafted QQ+F sheets in EAM hearts accelerated vascularization, reducing myocardial loss and cardiac fibrosis.