The wide range of multifunctionality of gal-3 inter alia being a biomarker of inflammation, atherosclerosis, fibrosis, oxidative stress, and many others, involved intensively in the pathogenesis of psoriasis, has prompted us to investigate the potential diagnostic and clinical usefulness of gal-3 in serum of psoriatics and its relationship with the disease severity, metabolic, or inflammatory indicators. Here, LGALS3 is linked to psoriasis.