As regards lactoferrin, its anti-inflammatory action has been studied by means of in vitro periodontitis models, as well as in clinical studies: lactoferrin shows strong in vitro anti-inflammatory properties against gingival fibroblasts infected with Prevotella intermedia, whereas the topical administration to patients suffering from periodontitis is able to decrease both the levels of cytokines in crevicular fluid (e.g., IL-6), as well as edema, bleeding, pocket depth, and gingival and plaque index, with a positive variation of clinical attachment levels [34,35,36]. The gene discussed is LTF; the disease is periodontitis.