For example, Zhou and colleagues showed that intraperitoneal injection of verapamil 25 mg/kg/day for 7 days was able to reduce meta-inflammation, hepatic steatosis and insulin resistance, inhibiting the activation of thioredoxin-interacting protein (TXNIP)/nod-like receptor protein 3 (NLRP3) inflammasome, in mice subjected to a high-fat diet for 10 weeks [54]. Here, TXNIP is linked to Insulin resistance.