FOXO1 and hepatocellular carcinoma: In fact, mouse hepatoma cells (Hepa1–6) treated with 2.5 μM dexamethasone for 2 h, displayed increased expression of MKP3 via the forkhead box protein O1 (FOXO1) and the same result was obtained in lean mice treated with 15 mg/kg dexamethasone for 28 days.