Lastly, it has been recently demonstrated that angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor), a primary downstream gene of GC receptor signaling pathway in both hepatocytes and adipocytes, is strictly linked with the GC-induced hepatic steatosis and hypertriglyceridemia. The gene discussed is ANGPTL4; the disease is hypertriglyceridemia.