The mean ± 2 SD of APE1/Ref-1 levels was significantly higher in the KD group (0.654 ± 0.265 ng/mL than in the fever group (0.459 ± 0.290 ng/mL) and healthy group (0.442 ± 0.199 ng/mL), and the differences were significant (p = 0.004). The gene discussed is APEX1; the disease is Fever.