AKT1 and endometriosis: Figure 7 summarizes our rationale and findings that inhibition in ribosome biogenesis either by blocking upstream PI3K/AKT/mTOR signaling or by direct shutdown of RNA polymerase-1 in a mouse model of endometriosis that presents human phenotypes [15]. Among the potential drugs tested in this study, GSK2126458 or CX5461 showed therapeutic effects on endometriosis growth (Figure 1) and associated inflammation (Figure 2, Figure 3 and Figure 5), resulting in suppression of nerve fiber growth (Figure 4) and pain relief (Figure 6).