Staton et al. [34] revealed that although epithelial expression of both NRP-1 and NRP-2 increased considerably across the adenoma–carcinoma sequence—ACS (p = 0.0007, respectively p < 0.002), only NRP-1 was associated with microvessel density—MVD (p = 0.0003), and was moderately connected with VEGF (p = 0.001). This evidence concerns the gene NRP1 and adenoma.