Based on gene count, we identified the top 29 pathways in the KEGG pathway enrichment analysis (Figure 1e), which were associated with insulin resistance and inflammation, such as TNF signaling, PI3K-Akt signaling, MAPK signaling, HIF-1 signaling, estrogen signaling, cAMP signaling, and mTOR signaling pathways. The gene discussed is AKT1; the disease is Insulin resistance.