The AUC values distinguishing participants with prodromal AD from those with aMCI Aβ- in the aMCI group were 0.650 for plasma NFL concentrations (cut-off value > 18.8) and 0.769 for plasma Aβ1–42 concentrations (cut-off value < 10.45), whereas the AUC value for plasma NFL/Aβ1–42 was 0.822 (cut-off value > 1.77) (Figure 2e–l and Table 3). Here, NEFL is linked to Alzheimer disease.