In particular, the ∆z-score for plasma NFL/Aβ1–42 was 0.87, suggesting more rapid changes than that in CSF t-Tau (∆z-score = 0.55) and p-Tau181 (∆z-score = 0.49) concentrations in patients with preclinical AD (Figure 3b). This evidence concerns the gene NEFL and Alzheimer disease.