NEFL and Alzheimer disease: The AUC values of plasma NFL concentrations (preclinical AD, AUC = 0.668; prodromal AD, AUC = 0.696; and AD dementia, AUC = 0.710) that distinguished the AD groups from the CN Aβ- group were not significantly increased, whereas those of plasma Aβ1–42 concentrations were significantly increased (Figure 2i–l and Table 3).