This study identified several novel genetic determinants of proteins that were associated with the FRS including the novel genetic association with plasma levels of apolipoprotein E. More recently, the aptamer platform was applied for the proteomic analysis of 1017 patients that were diagnosed with heart failure with concurrent reduced ejection fraction (HFrEF) for the prediction of risk of death or deteriorating heart failure [109]. This evidence concerns the gene APOE and heart failure.