CXCL8 and glioblastoma: Proteins angiogenin, IL-6, IL-8, TIMP-1, VEGF and TIMP-2 had higher concentrations in EVs than in the glioblastoma cells, and the first three were already previously associated with angiogenesis and increased malignancy in glioma, implying that microvesicles angiogenic effect could be partially promoted through angiogenic proteins [36].