To determine if muChem-162 overexpression can normalize NASH-associated upregulation of F4/80, CCL2, and TGFβ mRNA, gene expression of age-matched male mice fed either the control chow or the MCD diet for two weeks was compared with the mRNA levels of the AAV8-infected mice (Table 2). The gene discussed is TGFB1; the disease is metabolic dysfunction-associated steatohepatitis.