AKT1 and carcinoma: For instance, previous studies demonstrated that Ver-A had strong antiproliferative and proapoptotic effect on renal [22], hepatocellular [23], leukemia [24,25], and breast [26] carcinoma by blocking cell cycle progression via inhibiting cell cycle regulatory proteins cyclin D1/E, cyclin-dependent kinases inhibitor WAF1/21, or protein kinase B (AKT)/nuclear factor kappa B (NF-κB)/mammalian target of rapamycin (mTOR) prosurvival signaling, or by inducing apoptosis [27].