CXCL12 and ischemia: These studies have further demonstrated that the salvage of ischemic related organ dysfunction in these small and large animals was mainly through enhancing the angiogenesis and SDF-1 angiogenic factors which attracted the EPC mobilization from circulation into the ischemia zone (i.e., a homing phenomenon) for angiogenesis [22,23,24,25,26,27,32], resulting in an increase of the blood flow in the ischemic region.