Exosomes can also mediate CAF activation through the induction of endothelial-mesenchymal transition from melanoma cells [28], the transfer of miRNAs promoting β1-integrin-NF-κB signaling (from metastatic liver cancer cells) [29], cell motility and extracellular matrix remodeling pathways (breast cancer cells) [30] or SOCS1/JAK2/STAT3 signaling (melanoma cells) [31]. The gene discussed is JAK2; the disease is melanoma.