Particularly, EFV enhanced the production and secretion of IL-1β, a crucial feature of pathological conditions such as alcoholic liver disease and non-alcoholic fatty liver disease (NAFLD) [25,26], and induced SERPINE1 transcription via NF-κB, a parameter associated with enhancement of fibrogenesis in NAFLD [27]. This evidence concerns the gene NFKB1 and metabolic dysfunction-associated steatotic liver disease.