Particularly, EFV enhanced the production and secretion of IL-1β, a crucial feature of pathological conditions such as alcoholic liver disease and non-alcoholic fatty liver disease (NAFLD) [25,26], and induced SERPINE1 transcription via NF-κB, a parameter associated with enhancement of fibrogenesis in NAFLD [27]. The gene discussed is SERPINE1; the disease is alcoholic liver diseases.