CACNA1C and Timothy syndrome: These include Andersen–Tawil syndrome (LQT7, KCNJ2) in which skeletal developmental abnormalities are observed [54]; Timothy syndrome (LQT8, CACNA1C) with characteristic neurological, facial and limb features [106] and JLNS syndrome, associated with sensorineural deafness (KCNQ1-KCNE1 genes) [107].