Hematoxylin and eosin (H&E) staining revealed that all liver tumors in the kras+ or twist1a+/kras+ zebrafish ranged from normal liver morphology to HCC and included the following classes: normal, hyperplasia (HP), hepatocellular adenoma (HCA), and HCC (Figure 1A,G). Here, KRAS is linked to hepatocellular carcinoma.